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Using Xpert MTB/RIF

[ Vol. 9 , Issue. 3 ]


Mark P. Nicol, Andrew Whitelaw and Wendy Stevens   Pages 187 - 192 ( 6 )


Xpert MTB/RIF is an automated real-time polymerase chain reaction test for simultaneous detection of tuberculosis and rifampicin resistance. Xpert MTB/RIF has demonstrated excellent accuracy in clinical evaluation studies, but has reduced sensitivity for detection of smear-negative tuberculosis. Since sample processing and detection are largely automated, Xpert MTB/RIF is potentially suitable for implementation in resource-limited settings. There are, however, a number of practical constraints to the use of Xpert at the point-of-care. Xpert remains a relatively costly test, and clear demonstration of cost-effectiveness will be needed to support efforts to scale up testing in high burden countries.


Cost-effectiveness, detection, diagnosis, rifampicin, tuberculosis, Xpert MTB/RIF.


5.28 Falmouth, Faculty of Health Sciences, Anzio Road, Observatory, Cape Town, 7925, South Africa.

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