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Chest X-ray in Sarcoidosis: The Association of Age, Gender, and Ethnicity with Different Radiological Findings

[ Vol. 13 , Issue. 4 ]

Author(s):

Saif Aldeen AlRyalat*, Mohammad Al-Essa, Rawan Ghazal, Enas Abusalim, Dia Mobaideen, Samar Alrahmeh, Mariam Alatrash and Nathir Obaidat   Pages 241 - 246 ( 6 )

Abstract:


Background: Sarcoidosis is a granulomatous disease that primarily affects the lung and lymphatic systems of the body. The Chest X-ray (Roentgenology) is the most common first imaging modality used in the diagnostic approach and follow-up of sarcoidosis, and is still used to determine the stage of sarcoidois based on the classification system proposed by Scadding (1961).

Objective: We will assess the relation between different chest x-ray findings in sarcoidosis patients and both, demographic variables of sarcoidosis patients (age, gender, and race), along with different Scadding stages.

Method: We included data regarding cases in the case-control ACCESS study, including demographic and clinical data, in addition to X-ray findings. From those with a biopsy-confirmed diagnosis of sarcoidosis in the ACCESS trial, we excluded patients with diseases that might contribute to X-ray abnormalities, including cardiac and respiratory non-sarcoidosis diseases (e.g. asthma and chronic bronchitis). We also excluded sarcoidosis patients without lung involvement.

Results: A total of 499 patients were included in this study, of which 195 (39.1%) were men and 304 (60.9%) were women. We found that pleural abnormalities are most commonly associated with Scadding stage 2 (42.9%, p= 0.001), whereas Scadding stage 4 is associated with hilar retraction (52.8%, p< 0.001), bullae and bleps (73.7%, p< 0.001), and pulmonary artery enlargement (66.7%, p< 0.001). Finally, we also observed significant relations between demographic variables (age, gender, and race) and different imaging findings.

Conclusion: Upon interpreting chest X-ray of sarcoidosis patients, patients' age, gender, and race should be kept in mind, as demographic variables are associated with chest X-ray findings in those patients. Moreover, each Scadding stage is associated with several findings on chest X-ray in sarcoidosis patients and should be interpreted accordingly.

Keywords:

Chest X-ray, granulomatous disease, lymphadenopathy, roentgenology, sarcoidosis, scadding stages.

Affiliation:

University of Jordan, Amman, 4th Year Internal Medicine Resident, University of Jordan Hospital, University of Jordan, Amman, 4th Year Internal Medicine Resident, University of Jordan Hospital, University of Jordan, Amman, 4th Year Internal Medicine Resident, University of Jordan Hospital, University of Jordan, Amman, 4th Year Internal Medicine Resident, University of Jordan Hospital, University of Jordan, Amman, 4th Year Internal Medicine Resident, University of Jordan Hospital, University of Jordan, Amman, 4th Year Internal Medicine Resident, University of Jordan Hospital, University of Jordan, Amman, Respiratory Medicine, University of Jordan Hospital, University of Jordan, Amman

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