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Alpha-1 Antitrypsin Deficiency and Chronic Obstructive Pulmonary Disease: Between Overlaps, Phenotypes and Illnesses

[ Vol. 15 , Issue. 2 ]

Author(s):

Alexandru Corlateanu*, Serghei Covantev, Irina Caraivanova, Vlada Bodrug, Victor Botnaru, Joseph Varon and Nikolaos Siafakas   Pages 147 - 155 ( 9 )

Abstract:


Alpha-1 antitrypsin deficiency (AATD) or alpha-1 antitrypsin proteinase inhibitor (α1-Pi) deficiency, is a genetic disorder leading to a higher risk of pulmonary, hepatic and other organrelated diseases. The spectrum of diseases associated with AATD is large and includes pulmonary conditions (COPD, asthma, asthma-COPD overlap syndrome, bronchiectasis, etc.) as well as extrapulmonary (liver diseases, systemic vasculitis, rheumatoid arthritis, panniculitis, multiple sclerosis, peripheral neuropathy). We present a review of AATD focusing on its connection to other conditions.

Keywords:

Alpha-1 antitrypsin deficiency, COPD, phenotypes, illness, syndrome, bronchiectasis.

Affiliation:

Department of Respiratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Department of Respiratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Department of Respiratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Department of Respiratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Department of Respiratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Critical Care Services, United Memorial Medical Center and United General Hospital Professor of Acute and Continuing Care, The University of Texas Health Science Center at Houston, Professor of Clinical Medicine, The University of Texas Medical Branch at Galveston, President, Dorrington Medical Associates, PA, Houston, Texas, Department of Thoracic Medicine, University General Hospital, Heraklion



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