Submit Manuscript  

Article Details


Risk Factors Associated with Development of Pulmonary Arterial Hypertension and Corpulmonale in Patients with Chronic Obstructive Pulmonary Disease

Author(s):

Chaya S K , M Mahendra, T Thippeswamy, B S Jayaraj, K S Lokesh and P A Mahesh   Pages 1 - 10 ( 10 )

Abstract:


Background: Chronic Obstructive Pulmonary Disease is an important cause of morbidity and mortality globally. Onset of pulmonary hypertension and corpulmonale is associated with decreased survival in patients with COPD.

Objective: To assess risk factors associated with development of pulmonary hypertension and corpulmonale and to identify high risk phenotypes who may need early evaluation and intervention.

Methods: Consecutive adult patients with COPD were evaluated for factors influencing development of pulmonary hypertension and corpulmonale which included symptomatology, hospitalization in previous year, MMRC dyspnea grade, SGRQ score, 6 minute walk test, ABG,CRP, spirometry and echocardiography.

Results: We found Pulmonary Hypertension in 36(30%) patients and 27(22.5%) had corpulmonale. On multivariate analysis we found PaO2 ≤75 mm Hg and six minute walk test <80% predicted to be significantly associated with development of Pulmonary hypertension and we found hospitalization in the previous year to be significantly and independently associated with development of corpulmonale.

Conclusion: We observed hospitalization in previous year was an independent risk factor for development of corpulmonale and six-minute walk test <80% predicted, PaO2 <75 mm Hg were independent risk factors for development of pulmonary hypertension.

Keywords:

COPD, Pulmonary hypertension, Mortality, Corpulmonale, Sleep, Right ventricular systolic pressure (RVSP)

Affiliation:

Asst.Professor in Pulmonary Medicine, JSS Medical College, JSS University, Mysore, Asst. Professor in Pulmonary Medicine, Shimoga Institute of Medical Sciences, Shivamogga, Karnataka, Associate Professor, Department of Medicine, JSS Medical College, JSS University, Mysore, Professor of Pulmonary Medicine, JSS Medical College, JSS University, Mysore, Assistant Professor in Pulmonary Medicine, JSS Medical College, JSS University, Mysore, Professor and Head of Pulmonary Medicine, JSS Medical College, JSS University, Mysore



Read Full-Text article