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The Immunomodulatory Role of Vitamin D in Respiratory Diseases

[ Vol. 15 , Issue. 3 ]

Author(s):

Giulio Pulvirenti, Giuseppe Fabio Parisi*, Sara Manti, Amelia Licari, Michele Miraglia del Giudice, Carmelo Salpietro, Gian Luigi Marseglia and Salvatore Leonardi   Pages 238 - 245 ( 8 )

Abstract:


The growing interest in the new role of vitamin D, particularly as an immunomodulatory factor, has spurred basic research and the development of clinical trials to better understand the influence of supplementation on various diseases. Vitamin D is an important nutrient factor in human health due to its role in calcium metabolism regulation, cellular growth, differentiation and its fundamental discovered activity in immune functions. It has influenced different diseases, particularly inflammatory and autoimmune diseases, through immune response regulation, modulating innate and adaptive immunity.

The aim of this review was to explore the role of vitamin D in the main respiratory diseases in children such as asthma, chronic rhinosinusitis, cystic fibrosis and recurrent respiratory infections.

Keywords:

Asthma, cystic fibrosis, recurrent respiratory infections, respiratory disease, Vitamin D, immunomodulatory.

Affiliation:

Department of Clinical and Experimental Medicine, University of Catania, Catania, Department of Clinical and Experimental Medicine, University of Catania, Catania, Department of Clinical and Experimental Medicine, University of Catania, Catania, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Department of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Naples, Department of Pediatrics, University of Messina, Messina, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Department of Clinical and Experimental Medicine, University of Catania, Catania

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