Daniel Maranatha* and Nurkristi Permatasari Amin Pages 66 - 70 ( 5 )
Background: Asthma and asthma-COPD overlap (ACO) are heterogeneous airway obstruction. This study aims to differentiate ACO and adult-onset asthma based on pulmonary function tests, smoking history, and atopic status.
Method: This cross-sectional study of adult-onset asthma evaluated characteristics, such as bronchodilator reversibility test, the skin prick test, total serum IgE, and serum IL-13 levels of asthma patients who were current/former smokers with a smoking history of <10 packs-year and ≥10 packs-year and who also had taken FEV1 / FVC <0.7 post-bronchodilator.
Results: The data of 30 subjects were analyzed and divided into two groups (23 asthma and 7 ACO subjects). The ACO patients were older compared to asthma patients (63.4 ± 4.7 vs. 53.7 ± 7.7, p = 0.004). A higher percentage of men was found in ACO than in asthma (85.7% vs. 21.7%, p = 0.004). There was a difference in the cumulative number of cigarettes consumed in patients with ACO and asthma (19.4 ± 6.4 vs. 7.2 ± 2.6, p = 0.014). The ratio of FEV1 / FVC post-bronchodilator in ACO patients was significantly lower than in asthma patients (57.3 ± 6.9 vs. 65.5 ± 8.8, p = 0.033). There was no difference in the duration of the disease between ACO and asthma (7.2 ± 6.1 vs. 6.1 ± 5.5, p = 0.535).
Conclusion: Differences were seen in the number of cigarettes consumed and the ratio of FEV1/FVC in ACO and adult-onset asthma patients. The cumulative number of cigarettes consumed could be a distinguishing characteristic between ACO and asthma.
Asthma-chronic, obstructive, pulmonary disease, overlap syndrome, spirometry, smoking.
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital Surabaya, Surabaya, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital Surabaya, Surabaya