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Pathway of Inflammation due to Asbestiform Fiber “Fluoro-edenite” Exposure: An Update

[ Vol. 16 , Issue. 2 ]

Author(s):

Caterina Ledda*, Claudia Lombardo, Elisabetta A. Tendi, Maria Hagnas, Gianluca Paravizzini, Vera Filetti and Venerando Rapisarda   Pages 73 - 75 ( 3 )

Abstract:


Fluoro-edenite (FE) is an asbestos-like amphibole present in the bentonitic lavas extracted from a stone quarry in Biancavilla, a village sited in the Etnean Volcanic Area (Italy).

Thoracic pathologies are the results of excessive inflammatory processes that are the early response of the immune system to inhaled fibers. As demonstrated for asbestos, fibers may trigger immune system cells in an acute and/or chronic manner. This review aims to clarify the pathways of inflammation in workers exposed to FE fibers.

Based on the articles reviewed, it seems that a permanent stimulus created by repeatedly inhaling the FE fibers and their persistence in the body can act as a trigger both in promoting inflammatory processes and in the immunological induction of autoimmune disease.

Keywords:

Fluoro-edenite, biancavilla, mesothelioma, carcinogenesis, inflammation, cancer, cytokine.

Affiliation:

Department of Clinical and Experimental Medicine, University of Catania, Catania, Anatomy and Histology, Department of Biomedical Sciences and Biotechnologies, University of Catania, Catania, Clinical Laboratories “Girlando and Paravizzini”, Catania, Center for Life Course Health Research, University of Oulu, Oulu, Clinical Laboratories “Girlando and Paravizzini”, Catania, Anatomy and Histology, Department of Biomedical Sciences and Biotechnologies, University of Catania, Catania, Department of Clinical and Experimental Medicine, University of Catania, Catania

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