Alaa M. Hammad*, Walid Al-Qerem, Ameen Alassi and Dana Hyassat Pages 213 - 219 ( 7 )
Background: Type 2 diabetes mellitus (T2DM) is a chronic condition with an impairing effect on multiple organs. Numerous respiratory disorders have been observed in patients with T2DM. However, the effect of T2DM on pulmonary function is inconclusive.
Aims: In this study, we investigated the effect of T2DM on respiratory function and the correlation of glycemic control, diabetes duration and insulin intake.
Methods: 1500 patients were recruited for this study; 560 having T2DM for at least a year were included in the final data, in addition to 540 healthy volunteers. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% (FEF 25-75%), as well as FEV1/FVC ratio values were measured.
Results: A two-sample t-test showed that z-scores produced by Al-Qerem et al.’s equations for FEV1, FVC, and FEF 25-75% were significantly lower for the T2DM group than the control group (p < 0.01). FEV1/FVC ratio in the T2DM group was significantly higher (p < 0.01). Multiple linear regression analysis found that glycemic control represented by HbA1c as well as disease duration were negatively associated with the pulmonary function (p < 0.01). However, insulin intake was found to have no significant correlation with pulmonary function.
Conclusion: T2DM was linked to reduced pulmonary function and was consistent with a restrictive ventilation pattern. HbA1c, as well as disease duration, were found to be independent risk factors for reduced pulmonary function.
Diabetes, FVC, FEV1, HbA1c, T2DM, FEV1.
Department of Pharmacy, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Department of Pharmacy, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Department of Pharmacy, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman, National Center for Diabetes, Endocrinology and Genetics, Jordan University, Amman