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The effect of uphill and downhill aerobic exercises on serum Apolipoprotein A1 and Apolipoprotein B levels and their ratio in patients with chronic obstructive pulmonary disease

Author(s):

Rostam Yazdani, Hamid Marefati, Armita Shahesmaeili, Alireza Bagheri, Ahmad Alinaghi Langari*, Samira Nakhaei*, Mahmoud Amiri and Halimeh Kameshki  

Abstract:


Background: Chronic obstructive pulmonary disease (COPD) is a major health issue worldwide.

Introduction: This study aimed to evaluate the effect of aerobic exercises at steep surfaces on Apo A1 and Apo B serum levels and their ratio in COPD patients.

Methods: This interventional study was undertaken on 16 COPD patients. The sample was selected by using the random sampling method. Patients were randomly divided into 2 groups of 8 members: uphill and downhill. Spirometry was conducted prior to the exercises and pulmonary volumes were measured. Aerobic exercises (stationary bicycle and treadmill) were started 3 times a week for 8 weeks. The duration of exercises in each session was determined based on the patients’ ability (30-40 min). In the first and second group, exercises were performed on sloped surfaces that were downwards and upwards at a 10-degree angle, respectively. Blood samples were taken from the patients before and after the 8 weeks. Apo A1 and Apo B serum levels and Apo A1 to Apo B ratio were measured. Data were analyzed by SPSS software. P<0.05 was considered statistically significant.

Results: ApoA1/Apo B ratio in the uphill group before and after the intervention was 1.43±0.21 and 1.53±0.24 mg/dL, respectively, with P-value=0.36. In the downhill group, this value was 1.27±0.17 and 1.30±0.18, respectively, with a P-value=0.032.

Conclusion: In light of the results of the present study, incorporating downhill exercises in COPD patients' rehabilitation program can help improve pulmonary function and prevent atherosclerotic events.

Keywords:

Apolipoprotein A1, Apolipoprotein B, Chronic obstructive pulmonary disease, Downhill, Exercise, Uphill

Affiliation:

Department of Internal Medicine, School of Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Shahid Bahonar University Kerman, Department of Physical Education and Sport Science, Kerman, Student of Medicine, Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Clinical research development unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Kerman University of Medical Sciences, Kerman, Kerman University of Medical Sciences, Kerman



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